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Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E
- Source :
- Marine Drugs, Vol 19, Iss 519, p 519 (2021), Marine Drugs; Volume 19; Issue 9; Pages: 519, Marine Drugs
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The soft coral genus Sarcophyton contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A–E (1–5) were purified and characterized from an ethyl acetate extract of the red sea soft coral, Sarcophyton convolutum. Compounds were assemblies according to spectroscopic methods including FTIR, 1D- and 2D-NMR as well as HRMS. Metabolite cytotoxicity was tested against lung adenocarcinoma, cervical cancer, and oral-cavity carcinoma (A549, HeLa and HSC-2, respectively). The most cytotoxic compound, (4) was observed to be active against cell lines A549 and HSC-2 with IC50 values of 49.70 and 53.17 μM, respectively.
- Subjects :
- Aquatic Organisms
sarcoconvolutum A–E
Magnetic Resonance Spectroscopy
Sarcophyton convolutum
Stereochemistry
QH301-705.5
Metabolite
Ethyl acetate
Pharmaceutical Science
Antineoplastic Agents
Article
HeLa
Inhibitory Concentration 50
Structure-Activity Relationship
chemistry.chemical_compound
Cell Line, Tumor
Drug Discovery
Ic50 values
Animals
Cytotoxic T cell
Biology (General)
Cytotoxicity
Indian Ocean
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
cembrenoids
chemistry.chemical_classification
biology
Chemistry
Sarcophyton
cytotoxicity
Anthozoa
biology.organism_classification
Enzyme
Diterpenes
Drug Screening Assays, Antitumor
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 19
- Issue :
- 519
- Database :
- OpenAIRE
- Journal :
- Marine Drugs
- Accession number :
- edsair.doi.dedup.....10db1c4591bac5418cedadd93b051217