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P2 Receptors and Platelet Activation
- Source :
- The Scientific World Journal, Vol 2, Pp 424-433 (2002), The Scientific World Journal
- Publication Year :
- 2002
- Publisher :
- Hindawi Limited, 2002.
-
Abstract
- Adenosine diphosphate (ADP) plays a crucial role in hemostasis and thrombosis by activating platelets. In platelets, the classical P2T receptor is now resolved into three P2 receptor subtypes: the P2Y1, the P2Y12, and the P2X1 receptors. Both pharmacological and molecular biological approaches have confirmed the role of the P2Y1 and P2Y12 receptors in the ADP-induced platelet fibrinogen receptor activation. The P2Y1 and the P2X1 receptors independently contribute to platelet shape change. Whereas the P2Y12 receptor mediates the potentiation of dense granule release reaction, both the P2Y1 and P2Y12 receptors play an important role in the ADP-induced phospholipase A2 activation. The signaling events downstream of these receptors leading to the physiological effects remain elusive, and they are yet to be delineated.
- Subjects :
- Blood Platelets
Platelet Aggregation
P2T receptor
Fibrinogen receptor
ADP receptor
lcsh:Medicine
P2Y1 receptor
Immune receptor
030204 cardiovascular system & hematology
P2 receptor
lcsh:Technology
Phospholipases A
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Animals
Humans
Protease-activated receptor
Platelet activation
Receptor
lcsh:Science
Mini-Review Article
030304 developmental biology
General Environmental Science
Hemostasis
0303 health sciences
Receptors, Purinergic P2
Chemistry
lcsh:T
lcsh:R
Thrombosis
General Medicine
Purinergic signalling
Platelet Activation
3. Good health
Cell biology
Adenosine Diphosphate
Phospholipases A2
Metabotropic receptor
P2X1 receptor
Biochemistry
platelets
lcsh:Q
P2Y12 receptor
Subjects
Details
- Language :
- English
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- The Scientific World Journal
- Accession number :
- edsair.doi.dedup.....10da2f208fa4eae03fc3c955b516a6df