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A randomised, controlled study of peri-operative low dose s(+)-ketamine in combination with postoperative patient-controlled s(+)-ketamine and morphine after radical prostatectomy
- Source :
- Anaesthesia, 59, 3, pp. 222-8, Anaesthesia, 59, 222-8
- Publication Year :
- 2004
-
Abstract
- Item does not contain fulltext In a randomised, double-blind prospective study we compared the effects on postoperative pain and analgesic consumption of intra-operative s(+)-ketamine (100 microg.kg-1 bolus and a continuous infusion of 2 microg.kg-1.min-1) followed by postoperative patient-controlled analgesia with morphine (1 mg per bolus) plus s(+)-ketamine (0.5 mg per bolus), or intra-operative saline followed by postoperative patient-controlled analgesia morphine (1 mg per bolus) alone. A total of 28 male patients undergoing radical prostatectomy were studied. Morphine consumption, pain scores, pressure algometry and adverse effects were recorded for 48 h after surgery. Cumulative morphine consumption was significantly lower in the ketamine/morphine group (47.9 +/- 26.2 mg) than in the saline/morphine group (73.4 +/- 34.8 mg; p = 0.049). Pain scores at rest were significantly lower in the ketamine/morphine group across the 48-h study period (p = 0.01). No significant differences were found in pressure algometry measurements or the occurrence of adverse effects.
- Subjects :
- Adult
Male
Randomization
medicine.medical_treatment
Analgesic
Drug Administration Schedule
Perioperative Care
Bolus (medicine)
Double-Blind Method
Medicine
Neurosensory disorders [UMCN 3.3]
Humans
Ketamine
Prospective Studies
Adverse effect
Saline
Aged
Pain Measurement
Prostatectomy
Analgesics
Pain, Postoperative
Morphine
business.industry
Analgesia, Patient-Controlled
Perioperative
Middle Aged
Analgesics, Opioid
Drug Combinations
Anesthesiology and Pain Medicine
Anesthesia
business
medicine.drug
Subjects
Details
- ISSN :
- 00032409
- Volume :
- 59
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Anaesthesia
- Accession number :
- edsair.doi.dedup.....10d2f10ed48f256d474d997b94d90ba3