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Evolution and characteristics of the use of valproate in women of childbearing age with bipolar disorder: Results from the FACE-BD cohort
- Source :
- Journal of Affective Disorders, Journal of Affective Disorders, Elsevier, 2020, 276, pp.963-969. ⟨10.1016/j.jad.2020.07.078⟩, Journal of Affective Disorders, 2020, 276, pp.963-969. ⟨10.1016/j.jad.2020.07.078⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; Background: Valproate is associated with teratogenic and neurodevelopmental effects. Several agencies have restricted the conditions of its prescription in bipolar disorders (BD). We aimed to assess the evolution of valproate prescription and the clinical profile of BD women of childbearing age receiving valproate. Methods: Based on a large national cohort, we included all BD women 16–50 years old. Sociodemographic, clinical and pharmacological data were recorded. Logistic regression analyses were used to describe variables associated with valproate prescription. Results: Of the 1018 included women 16–50 years old, 26.9% were treated with valproate with a mean daily dosage of 968 mg. The prevalence of BD women using valproate was 32.6% before May 2015 and 17.3% after May 2015 (p
- Subjects :
- Adult
Pediatrics
medicine.medical_specialty
Adolescent
Bipolar disorder
[SDV]Life Sciences [q-bio]
medicine.medical_treatment
Logistic regression
National cohort
Young Adult
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Anticonvulsant
Humans
030212 general & internal medicine
Medical prescription
Women of childbearing age
ComputingMilieux_MISCELLANEOUS
Valproate
business.industry
Valproic Acid
Middle Aged
medicine.disease
3. Good health
Affect
Psychiatry and Mental health
Clinical Psychology
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Childbearing age
Cohort
Female
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 01650327 and 15732517
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders, Journal of Affective Disorders, Elsevier, 2020, 276, pp.963-969. ⟨10.1016/j.jad.2020.07.078⟩, Journal of Affective Disorders, 2020, 276, pp.963-969. ⟨10.1016/j.jad.2020.07.078⟩
- Accession number :
- edsair.doi.dedup.....10bc70d82ee5c1e82e8506e62ceaa2e7