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REM sleep enhancement induced by different procedures improves memory retention in rats
- Source :
- European Journal of Neuroscience. 18:2611-2617
- Publication Year :
- 2003
- Publisher :
- Wiley, 2003.
-
Abstract
- Growing evidence supports the idea that sleep following learning is critically involved in memory formation. Recent studies suggest that information acquired during waking is reactivated and possibly consolidated during subsequent sleep, especially during rapid-eye movement (REM) or paradoxical sleep (PS). Critical reviews, however, have questioned PS and memory relationships, particularly because of shortcomings of the PS deprivation paradigm applied in many studies. Therefore, in the present study we used an opposite strategy, i.e. we investigated the effects of PS enhancement on memory retention. In three experiments, we found that selective PS enhancement, induced by different procedures after discrimination training in rats, results in increased retention tested 24 h later. Moreover, calculated in all animals (n = 61), there was a highly significant correlation between post-training PS values and retention scores. Our results suggest that an experimentally induced increase of PS after learning facilitates memory consolidation.
- Subjects :
- Male
Sleep, REM
Corticotropin-Like Intermediate Lobe Peptide
Cholinergic Agonists
Electroencephalography
Discrimination Learning
Adrenocorticotropic Hormone
Memory
medicine
Animals
Rats, Wistar
Maze Learning
medicine.diagnostic_test
Electromyography
Reticular Formation
General Neuroscience
Retention, Psychology
Long-term potentiation
Memory retention
Sleep in non-human animals
Peptide Fragments
Rats
Sleep deprivation
Sleep enhancement
Synaptic plasticity
Sleep Deprivation
Carbachol
Memory consolidation
medicine.symptom
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 14609568 and 0953816X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- European Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....10bbbf0801b8608e23c50d169cb89d9b