Back to Search
Start Over
Effect of surgery-induced acute muscle wasting on postoperative outcomes and quality of life
- Source :
- The Journal of surgical research. 218
- Publication Year :
- 2017
-
Abstract
- Background Gastrectomy results in a significant loss of body composition in the long term, but the acute skeletal muscle wasting after gastrectomy has been rarely investigated. Moreover, the association between postoperative muscle wasting and quality of life (QOL) has never been reported. In the present study, we aimed to investigate the risk factors for acute muscle wasting after gastric cancer surgery and its effect on QOL and short-term postoperative outcomes. Methods We conducted a prospective study of patients who underwent curative gastrectomy for gastric cancer between June 2015 and December 2015. Skeletal muscle mass was measured by computed tomography within 1 month before and 1 week after surgery. QOL was assessed 1, 3, and 6 months postoperatively. Univariate and multivariate analyses were performed to identify the risk factors for clinically relevant muscle wasting (muscle wasting ≥10%). Results A total of 110 patients were included, in which 35 patients had muscle wasting ≥10% within 1 week after surgery. Age ≥65 years and diabetes were independent risk factors for muscle wasting ≥10%. Patients with muscle wasting ≥10% had a poorer QOL in terms of fatigue and physical functioning at 1 and 3 months postoperatively, as well as a higher incidence of postoperative complications, a higher incidence of handgrip strength reduction ≥10%, longer hospital stays, and higher costs. Conclusions Age ≥65 years and diabetes were independently associated with clinically relevant muscle wasting within 1 week after gastric cancer surgery. Clinically relevant muscle wasting was associated with a poorer QOL and short-term outcomes after surgery.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
03 medical and health sciences
Young Adult
0302 clinical medicine
Postoperative Complications
Quality of life
Risk Factors
Stomach Neoplasms
Diabetes mellitus
medicine
Humans
Prospective Studies
Young adult
Prospective cohort study
Wasting
Aged
Aged, 80 and over
business.industry
Incidence (epidemiology)
Skeletal muscle
Middle Aged
medicine.disease
Surgery
Muscular Atrophy
medicine.anatomical_structure
030220 oncology & carcinogenesis
Acute Disease
Multivariate Analysis
Quality of Life
030211 gastroenterology & hepatology
Gastrectomy
Female
medicine.symptom
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 10958673
- Volume :
- 218
- Database :
- OpenAIRE
- Journal :
- The Journal of surgical research
- Accession number :
- edsair.doi.dedup.....10b22bc6d2eb7a9d2596cd66ecfbdea9