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Hyperlipidemic Nephropathy Induced by Adriamycin: Effect of Melatonin Administration
- Source :
- Nephron. 76:345-350
- Publication Year :
- 1997
- Publisher :
- S. Karger AG, 1997.
-
Abstract
- The effect of melatonin (MEL) on the nephropathy and the oxidative stress induced by a single and high dose of Adriamycin (AD) has been studied in Wistar male rats. MEL (50 microg/kg/day) was injected intraperitoneally 3 and 7 days, respectively, before and after AD injection (20 mg/kg i.p.). Trunk blood was drawn and triglycerides, total cholesterol, phospholipids, high-density lipoprotein cholesterol, urea, creatinine, total protein, lipoperoxides, and reduced glutathione (GSH) levels and catalase activity (CAT) were determined in serum. In kidney homogenates, lipoperoxides, GSH, and CAT were measured as well as total protein in urine. AD administration resulted in hyperlipidemia and high-grade proteinuria and a marked increase in serum lipoperoxides, urea, and creatinine. In the kidney, the increase in lipoperoxides was accompanied by a significant decrease of GSH and CAT. The efficiency of MEL was specially remarkable in restoring GSH, CAT, and proteinuria to the levels of controls. These results confirm the involvement of free radicals in the pathogenesis of nephrotoxicity induced by AD. Likewise, they show the high antioxidative power of MEL and its marked effect on the prevention and suppression of this nephropathy.
- Subjects :
- Male
Lipid Peroxides
medicine.medical_specialty
Free Radicals
Hyperlipidemias
Kidney
Thiobarbituric Acid Reactive Substances
Antioxidants
Nephropathy
Nephrotoxicity
Melatonin
chemistry.chemical_compound
Internal medicine
Hyperlipidemia
medicine
Animals
Urea
Rats, Wistar
Creatinine
Proteinuria
business.industry
Kidney metabolism
Free Radical Scavengers
General Medicine
Glutathione
Catalase
medicine.disease
Lipids
Rats
Oxidative Stress
Endocrinology
chemistry
Doxorubicin
Nephrology
Kidney Diseases
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 14230186 and 00282766
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Nephron
- Accession number :
- edsair.doi.dedup.....10ab21041102a29184771fead6951f33