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Increased nitric oxide plasma concentration in dogs with naturally acquired chronic renal disease
- Source :
- Pesquisa Veterinária Brasileira v.37 n.8 2017, Pesquisa Veterinária Brasileira, Colégio Brasileiro de Patologia Animal (CBPA), instacron:EMBRAPA, Pesquisa Veterinária Brasileira, Vol 37, Iss 8, Pp 847-852, Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP, Pesquisa Veterinária Brasileira, Volume: 37, Issue: 8, Pages: 847-852, Published: AUG 2017
- Publication Year :
- 2017
- Publisher :
- FapUNIFESP (SciELO), 2017.
-
Abstract
- This study aimed to determine the amount of plasma nitric oxide in clinically stable dogs at different stages of chronic kidney disease (CKD). Five groups of dogs were studied, aged from 4 to 18, comprising of a control group composed of healthy animals (control n=17), group CKD stage 1 (DRC-1, n=12), group CKD stage 2 (CKD-2, n=10) group, CKD stages 3 (CRD-3, n=13) and Group CKD stage 4 (DRC-4, n=10). Dogs with CKD were clinically stable and received no treatment. Two blood samples were collected at 24 hours intervals (repeated measures) to obtain serum and plasma. The serum creatinine values were used to classify dogs as CG, CKD-1, CKD-2, CKD-3 and CKD-4, and were (1.02±0.02mg/dL), (1.07±0.04mg/dL), (1.81±0.03mg/dL), (3.40±0.15mg/dL) and (6.00±0.20mg/dL) respectively. The determination of nitric oxide (NO) was performed by dosing nitrate/nitrite indirectly, and used for measurement of nitrate according to the NO/ozone chemiluminescence. The data were submitted to ANOVA for nonparametric analysis(Kruskal-Wallis) (P
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
chronic renal disease
hypertension
Nitric oxide plasma concentration
030204 cardiovascular system & hematology
urologic and male genital diseases
Gastroenterology
Nitric oxide
azotemia
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
cães
Internal medicine
medicine
Nitrite
doença renal crônica
Creatinine
lcsh:Veterinary medicine
Proteinuria
General Veterinary
business.industry
creatinine
Repeated measures design
creatinina
medicine.disease
female genital diseases and pregnancy complications
030104 developmental biology
Endocrinology
chemistry
hipertensão
dog
lcsh:SF600-1100
Concentração plasmática
óxido nítrico
Azotemia
Analysis of variance
proteinuria
medicine.symptom
business
Kidney disease
Subjects
Details
- ISSN :
- 16785150 and 0100736X
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Pesquisa Veterinária Brasileira
- Accession number :
- edsair.doi.dedup.....10a6b0de479ed52e2055de8378d44cf4