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Gene polymorphisms and the prevalence of key periodontal pathogens
- Source :
- Journal of dental research. 86(5)
- Publication Year :
- 2007
-
Abstract
- Growing evidence suggests that individual genetic susceptibility may influence the host’s response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adults diagnosed with generalized aggressive periodontitis to study Fc receptors, formyl peptide receptor, Interleukin-6, tumor necrosis factor-α, and vitamin D receptor polymorphisms. The presence and viable numbers of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis were determined by culture, and their identities confirmed by PCR. Multiple logistic regressions revealed that both Fcγ receptor and IL-6 -174 polymorphisms were associated with increased odds of detecting A. actinomycetemcomitans, P. gingivalis, and T. forsythensis after adjustment for age, ethnicity, smoking, and periodontitis extent. These findings support the hypothesis that complex interactions between the microbiota and host genome may be at the basis of susceptibility to aggressive periodontitis.
- Subjects :
- 0301 basic medicine
Adult
Male
Receptors, Fc
Calcitriol receptor
Aggregatibacter actinomycetemcomitans
03 medical and health sciences
0302 clinical medicine
Antigens, CD
medicine
Genetic predisposition
Aggressive periodontitis
Bacteroides
Humans
Genetic Predisposition to Disease
Receptor
Periodontitis
General Dentistry
Porphyromonas gingivalis
Analysis of Variance
Polymorphism, Genetic
biology
Interleukin-6
Tumor Necrosis Factor-alpha
Receptors, IgG
030206 dentistry
biology.organism_classification
medicine.disease
Receptors, Formyl Peptide
030104 developmental biology
Logistic Models
Immunology
Actinobacillus
Receptors, Calcitriol
Female
Inflammation Mediators
Subjects
Details
- ISSN :
- 00220345
- Volume :
- 86
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of dental research
- Accession number :
- edsair.doi.dedup.....10a2b3297481341ef5bf834736c1a28c