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Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML
- Source :
- Case Reports in Hematology, Vol 2016 (2016), Case Reports in Hematology
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized byFLT3internal tandem duplication (FLT3ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantation. We report here the first case of SR ofFLT3ITD mutant AML in the literature. Our patient was an elderly woman with relapsedNPM1andFLT3ITD mutant AML whose disease underwent SR for a brief duration without precipitating cause. We review the potential immune mechanisms underlying SR in AML and discuss the implications for novel immunotherapeutic approaches forFLT3mutant AML.
- Subjects :
- Oncology
FLT3 Internal Tandem Duplication
medicine.medical_specialty
NPM1
Mutant
Spontaneous remission
Case Report
Disease
03 medical and health sciences
0302 clinical medicine
fluids and secretions
Internal medicine
hemic and lymphatic diseases
medicine
neoplasms
business.industry
lcsh:RC633-647.5
Myeloid leukemia
hemic and immune systems
General Medicine
lcsh:Diseases of the blood and blood-forming organs
Transplantation
030220 oncology & carcinogenesis
Immunology
embryonic structures
business
030215 immunology
Flt3 itd
Subjects
Details
- Language :
- English
- ISSN :
- 20906579 and 20906560
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Case Reports in Hematology
- Accession number :
- edsair.doi.dedup.....10a166c7898fee04c404a13cd901e7c6