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Impact of donor ABH-secretor status in ABO-mismatched living donor kidney transplantation
- Source :
- Transfusion. 56(9)
- Publication Year :
- 2015
-
Abstract
- BACKGROUND The ABO blood group is a major determinant in living donor kidney transplantation since AB antigens are expressed on renal tissue. Little attention has been directed to the ABH-secretor status of the donor kidney. As renal tissue is capable of secreting soluble ABH antigens in secretors, we examined the influence of the ABH-secretor status of kidney donors on outcome in ABO-mismatched living donor kidney transplantation. STUDY DESIGN AND METHODS We retrospectively analyzed all patients who underwent ABO-mismatched kidney transplantation at the University Hospital Basel from September 2005 to October 2013. The ABH-secretor status was determined in all donors by molecular genetic analysis. RESULTS Of all 55 patients who received transplants, we excluded all patients with donor-specific antibodies (n = 4). Forty-one donors were secretors (78%) and 11 were nonsecretors (22%). Recipients of ABH-secretor donor organs showed a significantly higher glomerular filtration rate throughout the first 6 months posttransplant, whereas no significant influence on posttransplant anti-A/B titers was found. Regression analysis revealed a significant impact on humoral rejection, whereas not on vascular or interstitial rejection in protocol kidney biopsies. CONCLUSION The donor ABH-secretor status may have an influence on early posttransplant renal function in patients undergoing ABO-mismatched living donor kidney transplantation. Further prospective studies with long-term follow-up are needed to elucidate involved pathomechanisms.
- Subjects :
- 0301 basic medicine
Adult
Graft Rejection
Male
medicine.medical_specialty
Immunology
Renal function
030230 surgery
Gastroenterology
ABO Blood-Group System
03 medical and health sciences
fluids and secretions
0302 clinical medicine
Antigen
ABO blood group system
Internal medicine
medicine
Living Donors
Immunology and Allergy
Humans
Prospective cohort study
Kidney transplantation
Retrospective Studies
Kidney
biology
business.industry
Retrospective cohort study
Hematology
Middle Aged
medicine.disease
Kidney Transplantation
030104 developmental biology
medicine.anatomical_structure
Blood Group Incompatibility
biology.protein
Female
Antibody
business
Subjects
Details
- ISSN :
- 15372995
- Volume :
- 56
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Transfusion
- Accession number :
- edsair.doi.dedup.....109d11d98aa7019ac3070b1edc9307e1