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Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 2854, p 2854 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The mitochondrial unfolded protein response (UPRmt) is a stress response mediated by the expression of genes such as chaperones, proteases, and mitokines to maintain mitochondrial proteostasis. Certain genetically modified mice, which defect mitochondrial proteins specifically in adipocytes, developed atrophy of the white adipose tissue, resisted diet-induced obesity, and had altered whole-body metabolism. UPRmt, which has beneficial functions for living organisms, is termed “mitohormesis”, but its specific characteristics and detailed regulatory mechanism have not been elucidated to date. In this review, we discuss the function of UPRmt in adipose atrophy (lipoatrophy), whole-body metabolism, and lifespan based on the concept of mitohormesis.
- Subjects :
- Proteases
Lipodystrophy
Adipose Tissue, White
Longevity
mitohormesis
Adipose tissue
White adipose tissue
Review
Biology
mitochondrial unfolded protein response (UPRmt)
Catalysis
Inorganic Chemistry
Mitochondrial Proteins
lcsh:Chemistry
Mice
Atrophy
Mitochondrial unfolded protein response
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Lipoatrophy
Gene
lcsh:QH301-705.5
Spectroscopy
lipoatrophy
Organic Chemistry
white adipose tissue (WAT)
General Medicine
medicine.disease
Computer Science Applications
Cell biology
Mitochondria
Proteostasis
lcsh:Biology (General)
lcsh:QD1-999
mitokine
Unfolded Protein Response
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 2854
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....10912430b49b2275032c1747187743fc