Back to Search
Start Over
Copper-catalyzed carbene/alkyne metathesis terminated with the Buchner reaction: synthesis of dihydrocyclohepta[b]indoles
- Source :
- Organic & Biomolecular Chemistry. 17:2326-2330
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- A copper-catalyzed selective cascade reaction of alkyne-tethered diazo compounds is reported for the direct and efficient construction of dihydrocyclohepta[b]indole skeletons under mild reaction conditions. A vinyl copper carbene is the key intermediate, which is generated in situ via carbene/alkyne metathesis (CAM) and terminated with the Buchner reaction.
- Subjects :
- Reaction conditions
Indole test
010405 organic chemistry
Organic Chemistry
chemistry.chemical_element
010402 general chemistry
01 natural sciences
Biochemistry
Medicinal chemistry
Copper
0104 chemical sciences
chemistry.chemical_compound
chemistry
Cascade reaction
Copper catalyzed
Alkyne metathesis
Diazo
Physical and Theoretical Chemistry
Carbene
Subjects
Details
- ISSN :
- 14770539 and 14770520
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Organic & Biomolecular Chemistry
- Accession number :
- edsair.doi.dedup.....10910b8ace487ce4e39ce330ed9440de