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Methodology for applied 4 MHz RF hyperthermia concomitant with 31P NMR spectroscopic monitoring of murine tumours
- Source :
- International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 20(6)
- Publication Year :
- 2004
-
Abstract
- It has been generally found that solid tumours in vivo are more susceptible to destruction by heat than normal tissues. Hyperthermia has, thus, been employed in the treatment of cancer either applied alone or in combination with other modalities such as chemotherapy and radiotherapy. However, the critical mechanism(s) by which heat sensitizes and kills cells in the solid tumour remains poorly defined. Magnetic resonance spectroscopic monitoring of tumour metabolism during application of hyperthermia may provide important insight into the response to hyperthermic challenge. The implementation of dual antenna-coil methodology that provides for NMR spectroscopic monitoring ( 31 P at 121 MHz) concomitant with applied 4 MHz RF hyperthermia in murine tumours is described herein, in some detail. This technology, which does not require advanced (and expensive) magnetic resonance imaging systems, should be readily adaptable by other laboratories with an interest in murine tumour models.
- Subjects :
- Hyperthermia
Cancer Research
Pathology
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Physiology
medicine.medical_treatment
Fibrosarcoma
Normal tissue
Body Temperature
Phosphates
Mice
In vivo
Physiology (medical)
Intensive care
Neoplasms
Medicine
Animals
Solid tumour
Mice, Inbred C3H
medicine.diagnostic_test
business.industry
Nucleotides
Magnetic resonance imaging
Hyperthermia, Induced
Hydrogen-Ion Concentration
medicine.disease
Radiation therapy
Concomitant
Cancer research
Female
business
Subjects
Details
- ISSN :
- 02656736
- Volume :
- 20
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
- Accession number :
- edsair.doi.dedup.....1088511018cced4e91430597a622716b