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Serotonin 7 Receptor Variants Are Not Associated with Response to Second-Generation Antipsychotics in Japanese Schizophrenia Patients
Serotonin 7 Receptor Variants Are Not Associated with Response to Second-Generation Antipsychotics in Japanese Schizophrenia Patients
- Publication Year :
- 2015
-
Abstract
- Background: Individual differences in serotonin 7 receptor (5-HT7R) may result in variable response to antipsychotics with 5-HT7R antagonism. This study investigated the relationship between single nucleotide polymorphisms (SNPs) in the 5-HT7R gene (HTR7) and the efficacy of second-generation antipsychotic drugs with a high affinity for this receptor in Japanese schizophrenia. Methods: Perospirone or aripiprazole was administered to 100 patients with schizophrenia in a randomized controlled study. All patients were genotyped for three candidate SNPs (rs12412496, rs7916403, and rs1935349). Patient improvement on the Positive and Negative Syndrome Scale (PANSS) total score at 12 weeks was assessed as the primary outcome. PANSS 5-factor scores were investigated as the secondary outcome. Results: Improvement on the PANSS total score and genetic polymorphisms showed no correlation. The rs12412496-rs7916403-rs1935349 A-T-A haplotype was correlated with worse improvement in the cognition score (haplotype frequency: 0.285, p = 0.046, permuted p = 0.043). Conclusion: Our results show that HTR7 variants are not related to the overall improvement in schizophrenia symptoms.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Efficacy
medicine.medical_treatment
Aripiprazole
5-HT
Single-nucleotide polymorphism
Isoindoles
Pharmacology
Polymorphism, Single Nucleotide
Linkage Disequilibrium
HTR7
law.invention
Antipsychotic
Asian People
Japan
Randomized controlled trial
law
Internal medicine
medicine
Humans
Precision Medicine
Polymorphism
Biological Psychiatry
Psychiatric Status Rating Scales
Positive and Negative Syndrome Scale
Pharmacogenetic
Haplotype
Middle Aged
Perospirone
Thiazoles
Treatment Outcome
Neuropsychology and Physiological Psychology
Second-generation antipsychotic
Psychiatry and Mental Health
Receptors, Serotonin
Schizophrenia
Female
Psychology
Pharmacogenetics
Antipsychotic Agents
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....10842f5bb96ffc1569e19417e9d0c60f