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GnRH-Agonist Ovulation Trigger in Patients Undergoing Controlled Ovarian Hyperstimulation for IVF with Stop GnRH-Agonist Combined with Multidose GnRH-Antagonist Protocol
- Source :
- Gynecologic and Obstetric Investigation. 86:427-431
- Publication Year :
- 2021
- Publisher :
- S. Karger AG, 2021.
-
Abstract
- Objective: This study aimed to characterize those patients undergoing the stop gonadotropin-releasing hormone (GnRH)-agonist combined with multidose GnRH-antagonist protocol, with suboptimal response to GnRH-agonist trigger in in vitro fertilization (IVF) cycles. Design: This is a cohort study. Setting: The study was conducted in a university hospital. Patients: All consecutive women admitted to our IVF unit from February 2020 through November 2020 who reached the ovum pick-up stage were reviewed. Interventions: Triggering final oocyte maturation by GnRH-ag alone (GnRH-ag trigger group), or combined with hCG (dual trigger group), in patients undergoing the stop GnRH-agonist combined with multidose GnRH-antagonist protocol was performed. Main Outcome Measure: The main outcome measure was LH level 12 h after the trigger. Results: Five out of the 32 patients (15.6%) demonstrated suboptimal response as reflected by LH levels 15 mIU/mL). Conclusions: The stop GnRH-agonist combined with GnRH-antagonist protocol enables the substitution of hCG with GnRH-ag for final oocyte maturation. However, caution should be taken in high responders, where the dual trigger with small doses of hCG (1,000–1,500 IU) should be considered, aiming to avoid suboptimal response (post-trigger LH levels
- Subjects :
- Ovulation
Agonist
endocrine system
Pregnancy Rate
medicine.drug_class
medicine.medical_treatment
media_common.quotation_subject
Fertilization in Vitro
Controlled ovarian hyperstimulation
Chorionic Gonadotropin
Cohort Studies
Gonadotropin-Releasing Hormone
Ovulation Induction
Pregnancy
Gonadotropin-releasing hormone agonist
medicine
Humans
media_common
In vitro fertilisation
business.industry
Obstetrics and Gynecology
Oocyte
medicine.anatomical_structure
Reproductive Medicine
Anesthesia
Female
business
hormones, hormone substitutes, and hormone antagonists
Hormone
Cohort study
Subjects
Details
- ISSN :
- 1423002X and 03787346
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Gynecologic and Obstetric Investigation
- Accession number :
- edsair.doi.dedup.....107ec244ce2876508f062c0e50481b8f