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Effect of Systemic Hypertension on Peripapillary RNFL Thickness in Patients With Diabetes Without Diabetic Retinopathy
- Source :
- Diabetes. 70:2663-2667
- Publication Year :
- 2021
- Publisher :
- American Diabetes Association, 2021.
-
Abstract
- Type 2 diabetes mellitus (T2DM) and hypertension (HTN) are both relatively common systemic diseases and cause damage to the retina, such as inner retina reduction and microvascular impairment. The purpose of this study was to identify peripapillary retinal nerve fiber layer (pRNFL) damage by diabetic neurodegeneration and the effects of HTN on the pRNFL thickness in patients with T2DM without clinical diabetic retinopathy. Subjects were divided into three groups: healthy control subjects (group 1), patients with T2DM (group 2), and patients with both diabetes and HTN (group 3). The pRNFL thickness was measured using optical coherence tomography and compared among each group. Linear regression analyses were performed to identify factors associated with pRNFL thickness. A total of 325 eyes were included: 143 eyes in the group 1, 126 eyes in group 2, and 56 eyes in group 3. The mean pRNFL thicknesses of each group were 96.1 ± 7.7, 94.4 ± 8.6, and 91.6 ± 9.6 μm, respectively (P = 0.003). In multivariate linear analyses, diabetes duration (β = −0.236; P = 0.018) and HTN (β = −3.766; P = 0.008) were significant factors affecting the pRNFL thickness in groups 2 and 3. Additionally, the HTN duration was significantly correlated with pRNFL thickness in group 3 (R2 = 0.121; P = 0.008). In conclusion, patients with T2DM with HTN showed thinner pRNFL thickness than those with T2DM only. Additionally, the duration of HTN was significantly correlated with pRNFL thickness in patients with both diabetes and HTN.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Visual Acuity
Nerve fiber layer
Type 2 diabetes
chemistry.chemical_compound
Diabetes mellitus
Ophthalmology
Healthy control
Internal Medicine
Humans
Medicine
In patient
cardiovascular diseases
Aged
Retrospective Studies
Glycated Hemoglobin
Diabetic Retinopathy
business.industry
Retinal
Diabetic retinopathy
Middle Aged
medicine.disease
Cross-Sectional Studies
medicine.anatomical_structure
Diabetes Mellitus, Type 2
chemistry
Hypertension
Female
business
Tomography, Optical Coherence
Retinal Neurons
Subjects
Details
- ISSN :
- 00121797
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....10763aa2ed0d6fea3d211ac3ac422fa6
- Full Text :
- https://doi.org/10.2337/db21-0491