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Employing Photocatalysis for the Design and Preparation of DNA‐Encoded Libraries: A Case Study
- Source :
- The Chemical Record. 21:616-630
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- This Personal Account describes the authors' foray into DNA-encoded libraries. The article addresses several key aspects of this hit generation technology, from the development of new synthetic methodology to the subsequent conception, design, and delivery of a DNA-encoded library. In particular, we have been engaged in adapting photocatalytic reactions to the idiosyncratic requirements of DNA-encoded chemistry. We have chosen one such methodology, namely a photocatalytic [2+2] cycloaddition reaction, to showcase how we employed property-based computational analyses to guide the selection and validation of building blocks for the production of a library. Ultimately, these novel bond disconnections and design principles led to the assembly of a DNA-encoded library that is composed of structurally diverse compounds within largely desirable property space and, therefore, well positioned to deliver novel chemical matter for drug discovery programs.
- Subjects :
- Personal account
010405 organic chemistry
business.industry
Drug discovery
General Chemical Engineering
Design elements and principles
DNA
General Chemistry
Photochemical Processes
010402 general chemistry
01 natural sciences
Biochemistry
Catalysis
0104 chemical sciences
Small Molecule Libraries
Drug Design
Materials Chemistry
Key (cryptography)
Combinatorial Chemistry Techniques
Software engineering
business
Gene Library
Subjects
Details
- ISSN :
- 15280691 and 15278999
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- The Chemical Record
- Accession number :
- edsair.doi.dedup.....10728fc7eb0789d60bc42ea8e82521f4