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Association of lymphocyte sub-populations with clustered features of metabolic syndrome in middle-aged Japanese men
- Source :
- Atherosclerosis. 173(2)
- Publication Year :
- 2003
-
Abstract
- To examine the relationship between altered cellular immune status and clustered features of the metabolic syndrome, we measured body mass index (BMI), serum concentrations of high-density lipoprotein-cholesterol, triglycerides, fasting plasma glucose, and blood pressure levels as well as differential leukocyte counts and lymphocyte sub-populations among 439 apparently healthy Japanese men aged 35-60 years. The components of the metabolic syndrome were defined based on the following criteria: BMI/=25.0 kg/m(2), fasting plasma glucose/=6.11 mmol/l, systolic blood pressure/=130 mmHg and/or diastolic blood pressure/=85 mmHg, high-density lipoprotein (HDL)-cholesterol1.03 mmol/l, and fasting triglyceride/=1.69 mmol/l. Counts of total leukocyte, total lymphocyte, CD3 + T cell, CD4 + T cell, and CD4 + CD45RO + T cell significantly correlated with the number of components of the metabolic syndrome (0, 1, 2, and 3+) after adjustment for age and smoking status. These findings were more evident among smokers than among non-smokers. The counts of total leukocytes, total lymphocytes and more specifically memory (CD4 + CD45RO + T) cells were elevated with clustered features of the metabolic syndrome in middle-aged men, which suggest the involvement of altered cellular immune status in the pathogenesis of atherosclerosis.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Cellular immunity
Lymphocyte
Sensitivity and Specificity
Body Mass Index
Cohort Studies
chemistry.chemical_compound
Japan
Risk Factors
T-Lymphocyte Subsets
Internal medicine
medicine
Cluster Analysis
Humans
Lymphocyte Count
Triglycerides
Probability
Metabolic Syndrome
Triglyceride
Vascular disease
business.industry
Cholesterol, HDL
Blood Pressure Determination
Middle Aged
medicine.disease
Endocrinology
medicine.anatomical_structure
Blood pressure
chemistry
Cardiovascular Diseases
Metabolic syndrome
Cardiology and Cardiovascular Medicine
business
Body mass index
Biomarkers
Lipoprotein
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 173
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....10644310103c4a82ad345a959cc649f7