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Synthesis and antimycobacterial activity of new S-alkylisothiosemicarbazone derivatives
- Source :
- Bioorganicmedicinal chemistry. 10(3)
- Publication Year :
- 2002
-
Abstract
- A new series of S-alkylisothiosemicarbazones of 3- and 4-pyridincarboxaldehyde and 4-fluoro- and 4-trifluoromethylbenzaldehyde was synthesized and evaluated for biological activity against various Mycobacterium strains. Inhibitory activity against Mycobacterium tuberculosis H37Rv ATCC 27294 and INH-R ATCC 35822 was compared with activity against clinical isolated Mycobacteria as well as against MOTT. Some of newly prepared compounds showed best inhibitory values against clinical isolated Mycobacteria, besides to low citotoxicity values.
- Subjects :
- Thiosemicarbazones
medicine.drug_class
Clinical Biochemistry
Pharmaceutical Science
Microbial Sensitivity Tests
Antimycobacterial
Biochemistry
Chemical synthesis
Microbiology
Mycobacterium tuberculosis
Structure-Activity Relationship
Drug Discovery
Chlorocebus aethiops
medicine
Structure–activity relationship
Animals
Molecular Biology
Mycobacteriaceae
Vero Cells
Antibacterial agent
biology
Chemistry
Organic Chemistry
Biological activity
bacterial infections and mycoses
biology.organism_classification
In vitro
Anti-Bacterial Agents
Molecular Medicine
Cell Division
Mycobacterium
Subjects
Details
- ISSN :
- 09680896
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry
- Accession number :
- edsair.doi.dedup.....10640e2f862f8c9fa63b9784f64d64e3