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Drug-coated balloon angioplasty for de novo small vessel disease including chronic total occlusion and bifurcation in real-world clinical practice
- Source :
- Cardiovascular Intervention and Therapeutics. 34:139-148
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The aim of this study is to validate the efficacy of drug-coated balloons (DCBs) for real-world de novo small vessel diseases including chronic total occlusion and bifurcation. DCB angioplasty has been reported to be effective in the treatment of de novo small vessel disease. However, the number of reports that have focused on complex lesions is limited. This observational study comprised consecutive patients who underwent DCB angioplasty for de novo small vessel disease with a reference diameter of less than 2.5 mm by visual estimation. Outcome parameters included late lumen loss, restenosis rate, and major adverse cardiac events, such as cardiac death, non-fatal myocardial infarction, and target lesion revascularization (TLR). Fifty-two patients underwent DCB angioplasty for 59 lesions with a reference vessel diameter of 1.93 ± 0.63 mm. Thirty-eight of the lesions (69%) were classified as type B2/C, including chronic total occlusions (20%) and bifurcations (33%). At the 8-month follow-up, late lumen loss was - 0.01 ± 0.44 mm with a restenosis rate of 20%. No cardiac deaths or myocardial infarctions were reported and only 5 (9%) angiographically driven TLRs were reported. DCB angioplasty offered an acceptable 8-month lumen patency and a stable clinical outcome for real-world complex de novo coronary diseases.
- Subjects :
- Male
medicine.medical_specialty
Paclitaxel
medicine.medical_treatment
Lumen (anatomy)
Coronary Artery Disease
Disease
030204 cardiovascular system & hematology
Coronary Angiography
Total occlusion
Coronary Restenosis
03 medical and health sciences
0302 clinical medicine
Coated Materials, Biocompatible
Japan
Restenosis
Internal medicine
Angioplasty
medicine
Humans
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Myocardial infarction
Angioplasty, Balloon, Coronary
Aged
medicine.diagnostic_test
business.industry
Interventional radiology
General Medicine
medicine.disease
Coronary Occlusion
Cardiology
Female
Small vessel
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 18684297 and 18684300
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Intervention and Therapeutics
- Accession number :
- edsair.doi.dedup.....10575708c4221efb66cb3f71de15d0ef
- Full Text :
- https://doi.org/10.1007/s12928-018-0534-9