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N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats
- Source :
- Repositório Institucional da Universidade Federal do Ceará (UFC), Universidade Federal do Ceará (UFC), instacron:UFC
- Publication Year :
- 2015
-
Abstract
- Kindling is a form of behavioral sensitization that is related to the progression of several neuropsychiatric disorders such as bipolar disorder. We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To do this female Wistar rats at postnatal day 30 received repeated injections of NIC 2mg/kg, i.p. every weekday for up to 19 days. NAC90, 180 or 270 mg/kg, i.p. was administered 30 min before NIC. The levels of glutathione (GSH), superoxide dismutase (SOD) activity, lipid peroxidation (LP) and nitrite were determined in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). The development of kindling occurred at a median time of 16.5 days with 87.5% of NIC animals presenting stage 5 seizures in the last day of drug administration. NAC270 prevented the occurrence of kindling. NIC-kindled animals presented decreased levels of GSH and increased LP in the PFC, HC and ST, while SOD activity was decreased in the ST. NAC180 or 270 prevented the alterations in GSH induced by NIC, but only NAC270 prevented the alterations in LP. Nitrite levels increased in the ST of NAC270 pretreated NIC-kindled animals. Taken together we demonstrated that NAC presents anti-kindling effects in female animals partially through the restoration of oxidative alterations.
- Subjects :
- Transtorno Bipolar
0301 basic medicine
medicine.medical_specialty
Nicotine
Striatum
Statistics, Nonparametric
Acetylcysteine
Superoxide dismutase
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Kindling, Neurologic
Hippocampus (mythology)
Animals
Drug Interactions
Nicotinic Agonists
Rats, Wistar
Biological Psychiatry
Nitrites
Psiquiatria Biológica
Pharmacology
biology
Dose-Response Relationship, Drug
Estradiol
business.industry
Kindling
Superoxide Dismutase
Excitação Neurológica
Glutathione
Free Radical Scavengers
Rats
030104 developmental biology
Endocrinology
chemistry
biology.protein
Female
Lipid Peroxidation
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 18784216
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Progress in neuro-psychopharmacologybiological psychiatry
- Accession number :
- edsair.doi.dedup.....1050db3a8532042e56a5cf4c73b67ae3