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Different patterns of p16INK4A and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia
- Source :
- Pancreas. 34(1)
- Publication Year :
- 2007
-
Abstract
- To examine aberrations and differences of cell cycle regulatory proteins between intraductal papillary-mucinous neoplasms (IPMNs) and pancreatic intraepithelial neoplasias (PanINs).In total, 47 IPMN lesions and 42 PanIN lesions were obtained from 26 patients with IPMN and 16 patients who underwent pancreatic surgery for invasive pancreatic ductal cancer or other diseases. They were subjected to conventional hematoxylin-eosin staining and immunostaining for p16INK4A and p53. The percentages of immunohistochemical positivity or negativity were compared between IPMN and PanIN, in accordance with the same histological grade of atypia. The Ki-67 labeling index was also counted in each lesion.Either the loss of p16INK4A expression or the overexpression of p53 was much more frequently observed among PanIN-3 than among carcinoma in situ in IPMN (P = 0.046 and 0.008, respectively). The Ki-67 labeling index was correlated with the histological grades of both PanINs and IPMNs (P = 0.0001 and P = 0.0001, respectively).There are different immunohistochemical expression patterns of p16INK4A and p53 between IPMNs and PanINs. These may substantiate their different genetic progressions to invasive carcinoma.
- Subjects :
- Oncology
Male
Pathology
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Pancreatic Intraepithelial Neoplasia
Cell-Cycle Regulatory Proteins
Endocrinology
Internal medicine
Internal Medicine
medicine
Carcinoma
Humans
Neoplasm Invasiveness
Cyclin-Dependent Kinase Inhibitor p16
Aged
Aged, 80 and over
Hepatology
business.industry
Middle Aged
medicine.disease
Adenocarcinoma, Mucinous
Immunohistochemistry
Carcinoma, Papillary
Pancreatic Neoplasms
Ki-67 Antigen
P53 protein
Adenocarcinoma
Female
Tumor Suppressor Protein p53
business
Carcinoma in Situ
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 15364828
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....104f01e3067db338a2dfc79b9962627e