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Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition
- Source :
- Neurobiol Aging
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Vascular endothelial growth factor (VEGF) is a complex signaling protein that supports vascular and neuronal function. Alzheimer's disease (AD) -neuropathological hallmarks interfere with VEGF signaling and modify previously detected positive associations between cerebral spinal fluid (CSF) VEGF and cognition and hippocampal volume. However, it remains unknown 1) whether regional relationships between VEGF and glucose metabolism and cortical thinning exist, and 2) whether AD-neuropathological hallmarks (CSF Aβ, t-tau, p-tau) also modify these relationships. We addressed this in 310 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (92 cognitively normal, 149 mild cognitive impairment, 69 AD; 215 CSF Aβ+, 95 CSF Aβ-) with regional cortical thickness and cognition measurements and 158 participants with FDG-PET. In Aβ + participants (CSF Aβ42 ≤ 192 pg/mL), higher CSF VEGF levels were associated with greater FDG-PET signal in the inferior parietal, and middle and inferior temporal cortices. Abnormal CSF amyloid and tau levels strengthened the positive association between VEGF and regional FDG-PET indices. VEGF also had both direct associations with semantic memory, as well as indirect associations mediated by regional FDG-PET signal to cognition.
- Subjects :
- Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Aging
medicine.medical_specialty
Amyloid
Amyloid beta
VEGF receptors
tau Proteins
Disease
Article
Executive Function
03 medical and health sciences
chemistry.chemical_compound
Cognition
0302 clinical medicine
Neuroimaging
Alzheimer Disease
Internal medicine
medicine
Humans
Semantic memory
Aged
Aged, 80 and over
Cerebral Cortex
Amyloid beta-Peptides
biology
business.industry
General Neuroscience
Middle Aged
Magnetic Resonance Imaging
Vascular endothelial growth factor
030104 developmental biology
Endocrinology
chemistry
Positron-Emission Tomography
biology.protein
Female
Neurology (clinical)
Geriatrics and Gerontology
business
Biomarkers
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....104ba681033f37c4d1c8cdd80b2b9531