Back to Search
Start Over
Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease
- Source :
- Thorax, 77(11), 1088-1097. BMJ PUBLISHING GROUP
- Publication Year :
- 2022
- Publisher :
- BMJ PUBLISHING GROUP, 2022.
-
Abstract
- BackgroundRisk factors for COPD in high-income settings are well understood; however, less attention has been paid to contributors of COPD in low-income and middle-income countries (LMICs) such as pulmonary tuberculosis. We sought to study the association between previous tuberculosis disease and COPD by using pooled population-based cross-sectional data in 13 geographically diverse, low-resource settings.MethodsWe pooled six cohorts in 13 different LMIC settings, 6 countries and 3 continents to study the relationship between self-reported previous tuberculosis disease and lung function outcomes including COPD (defined as a postbronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) below the lower limit of normal). Multivariable regressions with random effects were used to examine the association between previous tuberculosis disease and lung function outcomes.ResultsWe analysed data for 12 396 participants (median age 54.0 years, 51.5% male); 332 (2.7%) of the participants had previous tuberculosis disease. Overall prevalence of COPD was 8.8% (range 1.7%–15.5% across sites). COPD was four times more common among those with previous tuberculosis disease (25.7% vs 8.3% without previous tuberculosis disease, p1(−0.70, 95% CI −0.84 to −0.55), FVC (−0.44, 95% CI −0.59 to −0.29) and the FEV1:FVC ratio (−0.63, 95% CI −0.76 to −0.51) when compared with those without previous tuberculosis disease.ConclusionsPrevious tuberculosis disease is a significant and under-recognised risk factor for COPD and poor lung function in LMICs. Better tuberculosis control will also likely reduce the global burden of COPD.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Vital capacity
Tuberculosis
Population
Vital Capacity
URBAN
AIR-FLOW OBSTRUCTION
FEV1/FVC ratio
Pulmonary Disease, Chronic Obstructive
Risk Factors
Internal medicine
Forced Expiratory Volume
medicine
Humans
COPD
Risk factor
education
Tuberculosis, Pulmonary
History of tuberculosis
education.field_of_study
business.industry
ASSOCIATION
Middle Aged
medicine.disease
respiratory tract diseases
PREVALENCE
FUNCTION IMPAIRMENT
Cross-Sectional Studies
tuberculosis
Spirometry
Attributable risk
Female
business
COPD epidemiology
CHRONIC RESPIRATORY-DISEASE
Subjects
Details
- Language :
- English
- ISSN :
- 14683296 and 00406376
- Volume :
- 77
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Thorax
- Accession number :
- edsair.doi.dedup.....103f565e08bade88f0bbd7c31a9f75d1