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PLA nanovectors with encapsulated betulin: plant leaf extract-synthesized nanovectors are more efficacious than PVA-synthesized nanovectors
PLA nanovectors with encapsulated betulin: plant leaf extract-synthesized nanovectors are more efficacious than PVA-synthesized nanovectors
- Source :
- Biotechnology Letters. 38:259-269
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Betulin (BT) is an abundant triterpene found predominantly in the bark of Himalayan birch. It is difficult to deliver it in vivo because of its low aqueous solubility. We have therefore developed novel formulations of BT for improving its solubility, bioavailability and therapeutic efficacy. Poly-d,l-lactide nanovectors (PLA NVs) were synthesized using poly(vinyl alcohol) and Lonicera japonica leaf extract (LE) as a stabiliser and named as PLA-1 NVs and PLA-2 NVs. PLA-1 NVs and PLA-2 NVs were used for the encapsulation of betulin (BT) and named as BT-En-1 and BT-En-2 NVs. The encapsulation efficiency of BT-En-1 and BT-En-2 NVs were 99.3 and 100 % respectively. Prepared nanoformulations were physically stable. An in vitro study revealed 45 % BT was released over 24 h. BT had a prolonged release from BT-En-2 NVs as compared to BT-En-1 NVs. BT-En-2 NVs had better anticancerous activity against SiHa cells than BT-En-1 NVs. Developed BT-EN-2 NVs had better biocompatibility, excellent stability and enhanced release characteristics than BT-En-1 NVs.
- Subjects :
- Vinyl alcohol
Biocompatibility
Polymers
Polyesters
Antineoplastic Agents
Bioengineering
02 engineering and technology
01 natural sciences
Applied Microbiology and Biotechnology
Polyvinyl alcohol
chemistry.chemical_compound
Prolonged release
Cell Line, Tumor
0103 physical sciences
Aqueous solubility
Humans
In vitro study
Organic chemistry
Lactic Acid
Cell Proliferation
Betulin
010304 chemical physics
Plant Extracts
Epithelial Cells
General Medicine
021001 nanoscience & nanotechnology
Triterpenes
Bioavailability
Plant Leaves
Lonicera
chemistry
Polyvinyl Alcohol
Nanoparticles
0210 nano-technology
Biotechnology
Nuclear chemistry
Subjects
Details
- ISSN :
- 15736776 and 01415492
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Biotechnology Letters
- Accession number :
- edsair.doi.dedup.....102a58cc7564e6226d2b08a34033aab7
- Full Text :
- https://doi.org/10.1007/s10529-015-1981-3