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Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices
- Source :
- Scientific Reports
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- The sensitivity of localized surface plasmon resonance (LSPR) of metal nanostructures to adsorbates lends itself to a powerful class of label-free biosensors. Optical properties of plasmonic nanostructures are dependent on the geometrical features and the local dielectric environment. The exponential decay of the sensitivity from the surface of the plasmonic nanotransducer calls for the careful consideration in its design with particular attention to the size of the recognition and analyte layers. In this study, we demonstrate that short peptides as biorecognition elements (BRE) compared to larger antibodies as target capture agents offer several advantages. Using a bioplasmonic paper device (BPD), we demonstrate the selective and sensitive detection of the cardiac biomarker troponin I (cTnI). The smaller sized peptide provides higher sensitivity and a lower detection limit using a BPD. Furthermore, the excellent shelf-life and thermal stability of peptide-based LSPR sensors, which precludes the need for special storage conditions, makes it ideal for use in resource-limited settings.
- Subjects :
- Paper
Analyte
Materials science
Nanostructure
Nanotechnology
Biosensing Techniques
02 engineering and technology
010402 general chemistry
01 natural sciences
Article
Humans
Sensitivity (control systems)
Amino Acid Sequence
Surface plasmon resonance
Sweat
Plasmon
Detection limit
Nanotubes
Multidisciplinary
Troponin I
Surface Plasmon Resonance
021001 nanoscience & nanotechnology
0104 chemical sciences
Nanorod
Gold
Peptides
0210 nano-technology
Biosensor
Biomarkers
Protein Binding
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....1023aeab8523d254e96b97f86a5dcc92