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Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study
- Source :
- Journal of Infectious Diseases. 214:45-48
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval, .56–4.76).
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Adolescent
Antibodies, Viral
Risk Assessment
Serology
Young Adult
Major Articles and Brief Reports
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Immunology and Allergy
Prospective Studies
Young adult
Papillomaviridae
Prospective cohort study
Mexico
Aged
Proportional Hazards Models
biology
Proportional hazards model
business.industry
Papillomavirus Infections
Hazard ratio
HPV infection
virus diseases
Middle Aged
medicine.disease
biology.organism_classification
United States
female genital diseases and pregnancy complications
Oropharyngeal Neoplasms
030104 developmental biology
Infectious Diseases
030220 oncology & carcinogenesis
biology.protein
Antibody
business
Brazil
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 214
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....1020df5acc60292bfde91b47a4a00f7d