Back to Search
Start Over
Physicochemical compatibility studies of triclosan and flurbiprofen with excipients of pharmaceutical formulation using binary, ternary, and multi-combination approach
- Source :
- Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-16 (2021)
- Publication Year :
- 2021
- Publisher :
- SpringerOpen, 2021.
-
Abstract
- Background The aim of the study was to evaluate the suitability of triclosan (TCS) and flurbiprofen (FLB) with poly-ε-caprolactone (PCL), chitosan (CS), and Kolliphor® P188 (KP) for possible application in the design of nano-formulations. Results Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and scanning electron microscopy (SEM) revealed the physical characteristics of the various sample compositions without any apparent interaction. The Fourier transform infrared spectroscopy (FTIR)’s spectra of the physical mixtures showed their characteristic absorption bands with broadening and overlapping of bands in some instances, but no appearance of new bands was observed. Conclusion The study revealed the physical form stability of the evaluated components after the storage period and lack of definite pharmaceutical incompatibility between them. Thus, the selected drugs and excipients could be used for the development of pharmaceutical nano-formulations.
- Subjects :
- Materials science
Scanning electron microscope
Flurbiprofen
02 engineering and technology
RM1-950
Pharmaceutical formulation
01 natural sciences
Chitosan
chemistry.chemical_compound
Differential scanning calorimetry
Pharmacy and materia medica
medicine
Fourier transform infrared spectroscopy
Poly-ε-caprolactone
021001 nanoscience & nanotechnology
Triclosan
010406 physical chemistry
0104 chemical sciences
RS1-441
chemistry
Drug-Excipient
Compatibility studies
Therapeutics. Pharmacology
0210 nano-technology
Ternary operation
Powder diffraction
medicine.drug
Nuclear chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 23147253
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Future Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....101aac298296626a96dd83852296ed19