Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity

Authors :: Kara L. Lynch
Alan H.B. Wu
Cassandra Yun
Indrani Chakraborty
Yiqi Ruben Luo
Source :: Clinical Infectious Diseases, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 73, iss 9
Publication Year :: 2020
Publisher :: Oxford University Press (OUP), 2020.
Abstract: The kinetics of IgG avidity maturation during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was studied. The IgG avidity assay, using a novel label-free immunoassay technology, revealed a strong correlation between IgG avidity and days since symptom onset. Peak readings were significantly higher in severe than mild disease cases.

Subjects :: 0301 basic medicine
thin-film interferometry
Antibody Affinity
Antibodies, Viral
antibody avidity
Medical and Health Sciences
Severity of Illness Index
Immunoglobulin G
0302 clinical medicine
Viral
030212 general & internal medicine
Lung
medicine.diagnostic_test
biology
Brief Report
Biological Sciences
AcademicSubjects/MED00290
Infectious Diseases
Pneumonia & Influenza
Antibody
Microbiology (medical)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
030106 microbiology
chemical and pharmacologic phenomena
Microbiology
Antibodies
Vaccine Related
03 medical and health sciences
Disease severity
Biodefense
Severity of illness
medicine
Humans
Avidity
label-free immunoassay
SARS-CoV-2
business.industry
Prevention
COVID-19
Pneumonia
Kinetics
Emerging Infectious Diseases
Immunoglobulin M
Immunoassay
Immunology
biology.protein
Immunization
business

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