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The Problem of Microbial Dark Matter in Neonatal Sepsis
- Source :
- Emerging Infectious Diseases, Vol 26, Iss 11, Pp 2543-2548 (2020), Emerging Infectious Diseases
- Publication Year :
- 2020
- Publisher :
- Centers for Disease Control and Prevention, 2020.
-
Abstract
- Neonatal sepsis (NS) kills 750,000 infants every year. Effectively treating NS requires timely diagnosis and antimicrobial therapy matched to the causative pathogens, but most blood cultures for suspected NS do not recover a causative pathogen. We refer to these suspected but unidentified pathogens as microbial dark matter. Given these low culture recovery rates, many non-culture-based technologies are being explored to diagnose NS, including PCR, 16S amplicon sequencing, and whole metagenomic sequencing. However, few of these newer technologies are scalable or sustainable globally. To reduce worldwide deaths from NS, one possibility may be performing population-wide pathogen discovery. Because pathogen transmission patterns can vary across space and time, computational models can be built to predict the pathogens responsible for NS by region and season. This approach could help to optimally treat patients, decreasing deaths from NS and increasing antimicrobial stewardship until effective diagnostics that are scalable become available globally.
- Subjects :
- Group B Streptococcus
16S amplicon sequencing
neonatal sepsis
Epidemiology
diagnosis
lcsh:Medicine
Polymerase Chain Reaction
0302 clinical medicine
Klebsiella
bloodborne pathogens
Antimicrobial stewardship
030212 general & internal medicine
bacteria
Pathogen
Suggested citation for this article: Sinnar SA
Neonatal sepsis
Transmission (medicine)
Schiff SJ. The problem of microbial dark matter in neonatal sepsis. Emerg Infect Dis. 2020 Nov [date cited]. https://doi.org/10.3201/eid2611.200004
Antimicrobial
Anti-Bacterial Agents
Infectious Diseases
Perspective
Amplicon sequencing
Microbiology (medical)
polymicrobial infections
Staphylococcus aureus
030231 tropical medicine
total metagenomic sequencing
Biology
The Problem of Microbial Dark Matter in Neonatal Sepsis
lcsh:Infectious and parasitic diseases
03 medical and health sciences
molecular diagnosis
medicine
Escherichia coli
Humans
Computer Simulation
lcsh:RC109-216
DNA sequence analysis
Paenibacillus thiaminolyticus
cerebral palsy
RNA sequence analysis
lcsh:R
Infant
medicine.disease
Virology
point of care
antimicrobial stewardship
Metagenomics
Blood Culture
Until Effective
Subjects
Details
- Language :
- English
- ISSN :
- 10806059 and 10806040
- Volume :
- 26
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Emerging Infectious Diseases
- Accession number :
- edsair.doi.dedup.....100ce40e1a64448f64e07ccc9622e7ab