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The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis
- Source :
- International Journal of Inflammation, International Journal of Inflammation, Vol 2014 (2014)
- Publication Year :
- 2014
- Publisher :
- Hindawi Publishing Corporation, 2014.
-
Abstract
- Objective. Recent studies have demonstrated that enteric glial cells (EGC) participate in the homeostasis of the gastrointestinal tract. This study investigated whether enteroglial markers, including S100B protein and glial fibrillary acidic protein (GFAP), can serve as noninvasive indicators of EGC activation and disease activity in UC patients.Methods. This clinical prospective study included 35 patients with UC and 40 age- and sex-matched controls. The diagnosis of UC was based on standard clinical, radiological, endoscopic, and histological criteria. Clinical disease activity was evaluated using the Modified Truelove-Witts Severity Index. Serum samples were analyzed for human GFAP and S100B using commercial enzyme-linked immunosorbent assay kits.Results. GFAP was not detected in the serum of either UC patients or controls (P>0.05). However, we found a significant (P<0.001) decrease in the serum S100B levels in the UC patients. No correlation between the serum S100B level and the disease activity or duration was observed (P>0.05). The serum S100B levels did not differ between UC patients with active disease (24 patients, 68.6%) or in remission (11 patients, 31.4%) (P>0.05).Conclusions. Ulcerative colitis patients had significantly lower serum S100B levels, while GFAP was of no diagnostic value in UC patients.
- Subjects :
- medicine.medical_specialty
Pathology
Gastrointestinal tract
Glial fibrillary acidic protein
biology
Article Subject
business.industry
Serum samples
medicine.disease
Clinical disease
Gastroenterology
Ulcerative colitis
Internal medicine
medicine
biology.protein
lcsh:Pathology
Immunology and Allergy
Biomarker (medicine)
In patient
Prospective cohort study
business
lcsh:RB1-214
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20908040
- Database :
- OpenAIRE
- Journal :
- International Journal of Inflammation
- Accession number :
- edsair.doi.dedup.....10085c3ebcbada7c95b26e8c25a2e9a0
- Full Text :
- https://doi.org/10.1155/2014/986525