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Moxifloxacin-rifampicin combination for the treatment of non-staphylococcal Gram-positive orthopedic implant-related infections
- Source :
- Médecine et Maladies Infectieuses, Médecine et Maladies Infectieuses, Elsevier Masson, 2019, 49, pp.540-544. ⟨10.1016/j.medmal.2019.06.008⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Objective We aimed to describe the effectiveness and safety of the moxifloxacin–rifampicin combination in non-staphylococcal Gram-positive orthopedic implant-related infections. Methods Patients treated with the moxifloxacin–rifampicin combination for an implant-related infection from November 2014 to November 2016 were retrospectively identified from the database of the referral centers for bone and joint infections in Western France. Results Twenty-three cases of infection due to Streptococcus spp. (n = 12), Cutibacterium acnes (n = 6), and Enterococcus faecalis (n = 5) were included. Ten patients with hip prosthesis were included. Infection was polymicrobial in 11 cases. According to the MIC, moxifloxacin was 1.5 to 11.7 times as active as levofloxacin against non-staphylococcal Gram-positive bacteria. We reported an 81.8% success rate, and no severe adverse effect. Conclusion The moxifloxacin–rifampicin combination is a valuable alternative for the treatment of non-staphylococcal Gram-positive implant-related infections because of the good activity of moxifloxacin against these bacteria and the potential activity on the biofilm.
- Subjects :
- Adult
Male
medicine.medical_specialty
Prosthesis-Related Infections
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Moxifloxacin
Prosthesis
Enterococcus faecalis
03 medical and health sciences
Levofloxacin
Streptococcal Infections
Internal medicine
medicine
Humans
Orthopedic implant
Adverse effect
Gram-Positive Bacterial Infections
Aged
Retrospective Studies
Aged, 80 and over
0303 health sciences
biology
030306 microbiology
business.industry
Middle Aged
Propionibacteriaceae
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
biology.organism_classification
Anti-Bacterial Agents
3. Good health
Drug Combinations
Treatment Outcome
Infectious Diseases
Orthopedic surgery
Female
Hip Prosthesis
Rifampin
business
Rifampicin
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 0399077X
- Database :
- OpenAIRE
- Journal :
- Médecine et Maladies Infectieuses, Médecine et Maladies Infectieuses, Elsevier Masson, 2019, 49, pp.540-544. ⟨10.1016/j.medmal.2019.06.008⟩
- Accession number :
- edsair.doi.dedup.....0fd34297a21eb99cb1d9c6f2d40c9610