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The Unknown Unknowns: Recovering Gamma-Delta T Cells for Control of Human Immunodeficiency Virus (HIV)
- Source :
- Viruses, Vol 12, Iss 1455, p 1455 (2020), Viruses
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Recent advances in γδ T cell biology have focused on the unique attributes of these cells and their role in regulating innate and adaptive immunity, promoting tissue homeostasis, and providing resistance to various disorders. Numerous bacterial and viral pathogens, including human immunodeficiency virus-1 (HIV), greatly alter the composition of γδ T cells in vivo. Despite the effectiveness of antiretroviral therapy (ART) in controlling HIV and restoring health in those affected, γδ T cells are dramatically impacted during HIV infection and fail to reconstitute to normal levels in HIV-infected individuals during ART for reasons that are not clearly understood. Importantly, their role in controlling HIV infection, and the implications of their failure to rebound during ART are also largely unknown and understudied. Here, we review important aspects of human γδ T cell biology, the effector and immunomodulatory properties of these cells, their prevalence and function in HIV, and their immunotherapeutic potential.
- Subjects :
- 0301 basic medicine
gamma delta T cell
T cell
medicine.medical_treatment
Human immunodeficiency virus (HIV)
lcsh:QR1-502
HIV Infections
Review
Biology
medicine.disease_cause
Ligands
Vδ2
lcsh:Microbiology
Vδ1
03 medical and health sciences
0302 clinical medicine
In vivo
HLA Antigens
T-Lymphocyte Subsets
Virology
medicine
Humans
Gamma delta T cell
Antigens, Viral
Intraepithelial Lymphocytes
Tissue homeostasis
Effector
HIV
Immunotherapy
Acquired immune system
Phosphoproteins
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Immunology
Host-Pathogen Interactions
HIV-1
immunotherapy
Biomarkers
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 12
- Issue :
- 1455
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....0fce757bfeb6462aa22b347e0872179c