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Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte function
- Source :
- Journal of immunology (Baltimore, Md. : 1950). 167(6)
- Publication Year :
- 2001
-
Abstract
- Eosinophils are primarily thought of as terminal effectors of allergic responses and of parasite elimination. However, limited studies suggest a more discrete immunomodulatory role for this leukocyte during these inflammatory responses. In this investigation, we highlight the potential of eosinophils to act as APCs and thus modulators of allergic responses by influencing Th2 cell function. In response to Ag provocation of the allergic lung, eosinophils rapidly trafficked to sites of Ag deposition (airways lumen) and presentation (lung-associated lymph nodes and T cell-rich paracortical zones). Eosinophils from the allergic lung expressed class II MHC peptides, T cell costimulatory molecules (CD80 and CD86), and rapidly internalized and processed Ag that was sampled from within the airway lumen. Ag-loaded eosinophils promoted the production of IL-4, IL-5, and IL-13 in cocultures with in vitro-polarized Th2 cells and induced IL-5 production in a dose-dependent manner from Ag-specific CD4+ T cells isolated from allergic mice. In addition, Ag-loaded eosinophils primed for Th2 cell-driven allergic disease of the lung when transferred to naive mice. Thus, eosinophils have the potential to not only activate Th2 cells to release disease-modulating cytokines but also to assist in priming the immune system for allergic responses. This investigation highlights the potential of eosinophils to not only act as terminal effector cells but also to actively modulate allergic inflammation by amplifying Th2 cell responses.
- Subjects :
- Ovalbumin
T cell
Immunology
Mice, Transgenic
Biology
Lymphocyte Activation
Allergic inflammation
Mice
Immune system
Th2 Cells
Antigens, CD
Administration, Inhalation
medicine
Respiratory Hypersensitivity
Immunology and Allergy
Animals
Pulmonary Eosinophilia
Antigen-presenting cell
Interleukin 5
Lung
CD86
Antigen Presentation
Mice, Inbred BALB C
Membrane Glycoproteins
Chemotaxis
Histocompatibility Antigens Class II
respiratory system
Allergens
Specific Pathogen-Free Organisms
Eosinophils
Mice, Inbred C57BL
medicine.anatomical_structure
Interleukin 13
B7-1 Antigen
Cytokines
Immunization
B7-2 Antigen
Lymph Nodes
Bronchoalveolar Lavage Fluid
CD80
Subjects
Details
- ISSN :
- 00221767
- Volume :
- 167
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Accession number :
- edsair.doi.dedup.....0fcb7745ddf00d9244b6a7fdc2fa5a85