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Maternal Prenatal Iron Status and Tissue Organization in the Neonatal Brain
- Source :
- Pediatric research
- Publication Year :
- 2015
-
Abstract
- Background Children prenatally exposed to inadequate iron have poorer motor and neurocognitive development. No prior study to our knowledge has assessed the influence of maternal prenatal iron intake on newborn brain tissue organization in fullterm infants. Methods 3rd trimester daily iron intake was obtained using the Automated SelfAdministered 24hour Dietary Recall with n=40 healthy pregnant adolescents (14–19 years old). Cord blood ferritin was collected in a subsample (n=16). Newborn (m=39 gestational weeks at birth; range 37–41) Neonatal MRI scans were acquired on a 3.0 Tesla MR Scanner. Diffusion Tensor Imaging (DTI) slices were acquired to measure the directional diffusion of water indexed by fractional anisotropy (FA). Results Reported iron intake was inversely associated with newborn FA values (P ≤ .0001) predominantly in cortical gray matter. FA findings were similar using cord blood ferritin values. Conclusion Higher maternal prenatal iron intake accentuates, and lower intake attenuates, the normal age–related decline in FA values in gray matter, perhaps representing increasing dendritic arborization and synapse formation with higher iron intake. These DTI results suggest that typical variation in maternal iron outside the scope of standard clinical surveillance exerts subtle effects on infant brain development.
- Subjects :
- 0301 basic medicine
Male
Pediatrics
medicine.medical_specialty
Adolescent
Iron
Pregnancy Trimester, Third
Neurocognitive Disorders
Physiology
Gestational Age
Article
03 medical and health sciences
Young Adult
0302 clinical medicine
Pregnancy
Fractional anisotropy
Medicine
Humans
Young adult
biology
medicine.diagnostic_test
business.industry
Infant, Newborn
Gestational age
Brain
Magnetic resonance imaging
Hispanic or Latino
Maternal Nutritional Physiological Phenomena
medicine.disease
Fetal Blood
Diet
Ferritin
Pregnancy Complications
030104 developmental biology
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Cord blood
Pediatrics, Perinatology and Child Health
Ferritins
biology.protein
Anisotropy
Female
business
030217 neurology & neurosurgery
Iron, Dietary
Diffusion MRI
Subjects
Details
- Language :
- English
- ISSN :
- 15300447 and 00313998
- Volume :
- 79
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pediatric research
- Accession number :
- edsair.doi.dedup.....0fcad8f0c471c37f9eb964aef31bf36e