Clec2d Joins the Cell Death Sensor Ranks

Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. C.d.F. is supported by the AECC Foundation (INVES192DELF). Work in the DS laboratory is funded by the CNIC; the European Research Council (ERC 2016 Consolidator Grant 725091); the European Commission (635122-PROCROP H2020); Ministerio de Ciencia, Innovacion e Universidades (MICINN), Agencia Estatal de Investigacion, and Fondo Europeo de Desarrollo Regional (FEDER) (SAF2016-79040-R); Comunidad de Madrid (B2017/BMD-3733 Immunothercan-CM); FIS-Instituto de Salud Carlos III, MICINN, and FEDER (RD16/0015/0018-REEM); the Acteria Foundation; Atresmedia (Constantes y Vitales prize); and Fundacio La Marato de TV3 (201723). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the MICINN, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).