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Population structure of the fish-pathogenic bacterium Flavobacterium psychrophilum
- Source :
- HAL, Applied and Environmental Microbiology, Applied and Environmental Microbiology, American Society for Microbiology, 2008, 74 (12), pp.3702-3709. ⟨10.1128/AEM.00244-08⟩, Applied and Environmental Microbiology, 2008, 74 (12), pp.3702-3709. ⟨10.1128/AEM.00244-08⟩, 12. International Congress of Bacteriology and Applied Microbiology, 12. International Congress of Bacteriology and Applied Microbiology, Aug 2008, Istanbul, Turkey. 1 p., 2008, Applied and Environmental Microbiology, 2008, 74(12), pp.3702-3709, Applied and Environmental Microbiology, American Society for Microbiology, 2008, 74(12), pp.3702-3709
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Abstract
- Flavobacterium psychrophilum is currently one of the main bacterial pathogens hampering the productivity of salmonid farming worldwide, and its control mainly relies on antibiotic treatments. To better understand the population structure of this bacterium and its mode of evolution, we have examined the nucleotide polymorphisms at 11 protein-coding loci of the core genome in a set of 50 isolates. These isolates were selected to represent the broadest possible diversity, originating from 10 different host fish species and four continents. The nucleotide diversity between pairs of sequences amounted to fewer than four differences per kilobase on average, corresponding to a particularly low level of diversity, possibly indicative of a small effective-population size. The recombination rate, however, seemed remarkably high, and as a consequence, most of the isolates harbored unique combinations of alleles (33 distinct sequence types were resolved). The analysis also showed the existence of several clonal complexes with worldwide geographic distribution but marked association with particular fish species. Such an association could reflect preferential routes of transmission and/or adaptive niche specialization. The analysis provided no clues that the initial range of the bacterium was originally limited to North America. Instead, the historical record of the expansion of the pathogen may reflect the spread of a few clonal complexes. As a resource for future epidemiological surveys, a multilocus sequence typing website based on seven highly informative loci is available.
- Subjects :
- BACTERIAL
Range (biology)
[SDV]Life Sciences [q-bio]
EPIDEMIOLOGY MOLECULAR
Flavobacterium psychrophilum
Applied Microbiology and Biotechnology
Genome
Bacterial cold water disease
Nucleotide diversity
Fish Diseases
FLAVOBACTERIUM PSYCHROPHILUM
Flavobacteriaceae Infections
[MATH]Mathematics [math]
Pathogen
Phylogeny
ComputingMilieux_MISCELLANEOUS
Recombination, Genetic
[SDV.EE]Life Sciences [q-bio]/Ecology, environment
Genetics
Molecular Epidemiology
0303 health sciences
Ecology
biology
ALLELE
Biotechnology
DNA, Bacterial
Genotype
Molecular Sequence Data
Flavobacterium
03 medical and health sciences
Bacterial Proteins
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
[INFO]Computer Science [cs]
Evolutionary and Genomic Microbiology
14. Life underwater
Alleles
030304 developmental biology
Polymorphism, Genetic
030306 microbiology
Sequence Analysis, DNA
ANIMAL
DNA
biology.organism_classification
BACTERIAL PROTEIN
CLUSTER ANALYSIS
Multilocus sequence typing
Food Science
Subjects
Details
- ISSN :
- 00992240 and 10985336
- Database :
- OpenAIRE
- Journal :
- HAL, Applied and Environmental Microbiology, Applied and Environmental Microbiology, American Society for Microbiology, 2008, 74 (12), pp.3702-3709. ⟨10.1128/AEM.00244-08⟩, Applied and Environmental Microbiology, 2008, 74 (12), pp.3702-3709. ⟨10.1128/AEM.00244-08⟩, 12. International Congress of Bacteriology and Applied Microbiology, 12. International Congress of Bacteriology and Applied Microbiology, Aug 2008, Istanbul, Turkey. 1 p., 2008, Applied and Environmental Microbiology, 2008, 74(12), pp.3702-3709, Applied and Environmental Microbiology, American Society for Microbiology, 2008, 74(12), pp.3702-3709
- Accession number :
- edsair.doi.dedup.....0fbe3cd23d21b77e8c4977873f3694bb