Back to Search
Start Over
Radiofrequency Ablation of Breast Cancer: A Retrospective Study
- Source :
- Clinical breast cancer. 18(4)
- Publication Year :
- 2017
-
Abstract
- Purpose To validate the safety and efficacy of percutaneous radiofrequency ablation (RFA) of breast carcinomas. Methods This retrospective study was conducted by the Breast Cancer Society for Minimally Invasive Therapy following approval from institutional review boards, and with the written informed consent of patients. A total of 386 patients with breast cancer treated with RFA at 10 institutions between July 2003 and June 2009 were identified and included in the analysis. Patients underwent a standard RFA procedure with ultrasound guidance and were followed up every 6 to 12 months. In this study, feasibility of RFA procedure and related safety and ipsilateral breast tumor recurrence (IBTR) were examined. Fisher exact or χ2 test evaluated associations between clinicopathological factors and IBTR, and local recurrence-free survival was estimated using the Kaplan-Meier method. Results RFA-related adverse events included local pain in 9 patients, skin burns in 15, and nipple retraction in 7. Patients were followed for a median of 50 months. IBTR was more frequently observed in patients with initial tumor sizes > 2 cm (3 of 30, 10%) than in those with initial tumors ≤ 2 cm (8 of 355, 2.3%; P = .015). IBTR-free rates 5 years after RFA were 97%, 94%, and 87% in patients with initial tumor sizes ≤ 1.0 cm, 1.1 to 2.0 cm, and > 2.0 cm, respectively. Conclusions RFA in breast cancer is a safe and promising minimally invasive treatment for tumors ≤ 2 cm in diameter. Further studies are needed to optimize the technique and evaluate its future role as local therapy.
- Subjects :
- Adult
Cancer Research
medicine.medical_specialty
Percutaneous
Radiofrequency ablation
Breast Neoplasms
030218 nuclear medicine & medical imaging
law.invention
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Breast cancer
law
Risk Factors
Medicine
Humans
In patient
Adverse effect
Fisher's exact test
Ultrasonography, Interventional
Aged
Retrospective Studies
Aged, 80 and over
Radiofrequency Ablation
business.industry
Retrospective cohort study
Middle Aged
medicine.disease
Surgery
Survival Rate
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Ipsilateral breast
symbols
Feasibility Studies
Female
business
Subjects
Details
- ISSN :
- 19380666
- Volume :
- 18
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical breast cancer
- Accession number :
- edsair.doi.dedup.....0fb113b58cfd140ca4b5df9c5397e4c1