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Antigenic Diversity of Hepatitis B Virus Strains of Genotype F in Amerindians and Other Population Groups from Venezuela
- Source :
- Journal of Clinical Microbiology. 36:648-651
- Publication Year :
- 1998
- Publisher :
- American Society for Microbiology, 1998.
-
Abstract
- The adw4 subtype of hepatitis B virus (HBV) belongs to a unique genomic group (genotype F) representing the original HBV strains from the New World. Data regarding the prevalence of this subtype among HBV carriers in South America are, however, scarce, and those concerning HBV genotype F are based on only a few samples from Latin America. In this study, serum samples were obtained from 141 hepatitis B surface antigen (HBsAg) carriers from Amerindians and urban populations from Venezuela. The HBsAg subtype was identified with monoclonal antibodies in 105 samples, and the HBV genotype was identified by reverse-phase hybridization with DNA fragments in 58 samples. The adw4 subtype was highly prevalent in the population studied (75%); among the Amerindians, the prevalence was 97%. The adw2 subtype was also present (10%), while other subtypes (ayw3 and ayw4) were only occasionally found. The HBV subtype was associated with the expected genotype in most cases (80%), and thus genotype F was highly prevalent. Sequencing of viral strains that gave genotypes unpredicted by the HBsAg subtyping confirmed seven of them as belonging to not previously described genotype-subtype associations: namely, adw2 and ayw4 within genotype F.
- Subjects :
- Microbiology (medical)
Hepatitis B virus
HBsAg
Genotype
Population
medicine.disease_cause
Orthohepadnavirus
Pregnancy
Virology
medicine
Humans
Pregnancy Complications, Infectious
education
education.field_of_study
Hepatitis B Surface Antigens
biology
Indians, South American
virus diseases
Hepatitis B
Venezuela
medicine.disease
biology.organism_classification
Antigenic Variation
digestive system diseases
Subtyping
Amino Acid Substitution
Hepadnaviridae
Female
Sequence Analysis
Subjects
Details
- ISSN :
- 1098660X and 00951137
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....0faca46f7e657c880e38c1555851cb50