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Recurrent biliary acute pancreatitis is frequent in a real-world setting
- Publication Year :
- 2018
- Publisher :
- Elsevier B.V., 2018.
-
Abstract
- Background Data about recurrent acute pancreatitis (RAP) are limited. Aims To evaluate the rate of RAP and associated factors. Methods Single-centre prospective study of consecutive patients at first episode of acute pancreatitis (AP) being followed-up. Results Of 266 consecutive AP patients, (47% biliary, 15.4% alcoholic, 14.3% idiopathic) 66 (24.8%) had RAP in a mean follow-up of 42 months; 17.9% of recurrences occurred within 30 days from discharge. Age, gender, smoking and severity of first AP were not associated with RAP risk. The rate of biliary RAP was 31.3% in patients who did not receive any treatment, 18% in those treated with ERCP only, 16% in those who received cholecystectomy only, and 0% in those treated both with surgery and ERCP. Patients with biliary AP who received cholecystectomy had a significantly longer time of recurrence-free survival and reduced recurrence risk (HR = 0.45). In patients with alcoholic AP, the rate of recurrence was lower in those who quit drinking (5.8% vs 33%; p = 0.05). The alcoholic aetiology was associated with a higher risk of having >2 RAP episodes. Conclusion RAP occurs in about 25% of cases, and failure to treat biliary aetiology or quitting drinking is associated with increased recurrence risk.
- Subjects :
- medicine.medical_specialty
recurrence
acute pancreatitis
medicine.medical_treatment
Biliary acute pancreatitis
pancreatitis
cholecystectomy
Gastroenterology
Recurrence risk
03 medical and health sciences
cholangiopancreatography
0302 clinical medicine
disease progression
male
Internal medicine
italy
middle aged
Medicine
risk factors
Prospective cohort study
humans
acute disease
endoscopic retrograde
treatment failure
First episode
Cholangiopancreatography, Endoscopic Retrograde
biliary acute pancreatitis
ercp
Hepatology
business.industry
adult
aged
alcohol drinking
female
follow-up studies
kaplan-meier estimate
prospective studies
Background data
medicine.disease
030220 oncology & carcinogenesis
Etiology
Acute pancreatitis
030211 gastroenterology & hepatology
Cholecystectomy
sense organs
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0fabd14c4369a54266b1c018c4ae2d92