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Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations
- Source :
- Accounts of Chemical Research. 55:2892-2903
- Publication Year :
- 2022
- Publisher :
- American Chemical Society (ACS), 2022.
-
Abstract
- ConspectusNearly a century after its first description, configurationally stable axial chirality remains a rare feature in marketed drugs. In the development of the KRAS
Details
- ISSN :
- 15204898 and 00014842
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Accounts of Chemical Research
- Accession number :
- edsair.doi.dedup.....0fa33be4d8cb13730846b9101f1da93e