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HiGlass: Web-based Visual Exploration and Analysis of Genome Interaction Maps

Authors :
Kerpedjiev, Peter
Lekschas, Fritz
McCallum, Chuck
Dinkla, Kasper
Strobelt, Hendrik
Luber, Jacob M
Ouellette, Scott B
Azhir, Alaleh
Kumar, Nikhil
Hwang, Jeewon
Lee, Soohyun
Alver, Burak H
Pfister, Hanspeter
Park, Peter J
Gehlenborg, Nils
Luber, Jacob M.
Ouellette, Scott B.
Alver, Burak H.
Mirny, Leonid A.
Park, Peter J.
Abdennur, Nezar Alexander
Mirny, Leonid A
Institute for Medical Engineering and Science
Massachusetts Institute of Technology. Computational and Systems Biology Program
Massachusetts Institute of Technology. Department of Physics
Abdennur, Nezar Alexander
Mirny, Leonid A
Source :
Genome Biology, Vol 19, Iss 1, Pp 1-12 (2018), BioMed Central, Genome Biology
Publication Year :
2017
Publisher :
Cold Spring Harbor Laboratory, 2017.

Abstract

We present HiGlass, an open source visualization tool built on web technologies that provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps alongside 1D genomic tracks, allowing users to combine various data types, synchronize multiple visualization modalities, and share fully customizable views with others. We demonstrate its utility in exploring different experimental conditions, comparing the results of analyses, and creating interactive snapshots to share with collaborators and the broader public. HiGlass is accessible online at http://higlass.io and is also available as a containerized application that can be run on any platform.<br />National Institutes of Health (U.S.) (U01 CA200059)<br />National Institutes of Health (U.S.) (R00 HG007583)<br />National Institutes of Health (U.S.) (U54 HG007963)

Details

Database :
OpenAIRE
Journal :
Genome Biology, Vol 19, Iss 1, Pp 1-12 (2018), BioMed Central, Genome Biology
Accession number :
edsair.doi.dedup.....0f9eedc23f90f094f57af35ff67d2922