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Role of nuclear factor kappaB in intestine injury induced by hepatic ischemia reperfusion
- Source :
- Journal of Huazhong University of Science and Technology [Medical Sciences]. 24:284-285
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- The role of nuclear factor kappaB in intestine injury induced by hepatic ischemia reperfusion was investigated. Eighteen male Wistar rats were divided into 3 groups randomly: sham operation group (group A), hepatic ischemia reperfusion group (group B) and hepatic ischemia reperfusion plus pyrrolidine dithiocarbamate (PDTC) group (group C). The rats in group A were only subjected to laparotomy, those in group B underwent partial hepatic ischemia reperfusion (ischemia for 1 h and reperfusion for 2 h) and those in group C underwent the same procedure as that of group B but received PDTC 200 mg/kg i.v. before and after ischemia. After reperfusion, tissues of jejunum and venous blood were obtained for measurement of TNF-alpha, MDA and MPO. The levels of TNF-alpha in jejunum and venous blood, the levels of MPO in jejunum in group B were significantly higher than those in group A and group C (P0.05). There was no significant different in the levels of MDA between group B and group C. The severity of histological intestinal injury in group B and group C was similar. Hepatic ischemia reperfusion caused intestine injury, NF-kappaB may play an important role in this course and the targeting of upstream components of the inflammatory response, such as NF-kappaB, may have important therapeutic applications.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Biomedical Engineering
Ischemia
Biochemistry
Gastroenterology
Group A
Group B
Biomaterials
Jejunum
Random Allocation
chemistry.chemical_compound
Pyrrolidine dithiocarbamate
Internal medicine
Laparotomy
Genetics
medicine
Animals
Rats, Wistar
Earth-Surface Processes
business.industry
NF-kappa B
Venous blood
medicine.disease
Rats
Hepatic ischemia
Intestines
medicine.anatomical_structure
Liver
chemistry
Reperfusion Injury
Anesthesia
business
Subjects
Details
- ISSN :
- 19931352 and 16720733
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Huazhong University of Science and Technology [Medical Sciences]
- Accession number :
- edsair.doi.dedup.....0f9b53bea0df71467bf32ad904f06ef9