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Exponential growth and selection in self-replicating materials from DNA origami rafts
- Source :
- Nature Materials. 16:993-997
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Self-replication and evolution under selective pressure are inherent phenomena in life, and but few artificial systems exhibit these phenomena. We have designed a system of DNA origami rafts that exponentially replicates a seed pattern, doubling the copies in each diurnal-like cycle of temperature and ultraviolet illumination, producing more than 7 million copies in 24 cycles. We demonstrate environmental selection in growing populations by incorporating pH-sensitive binding in two subpopulations. In one species, pH-sensitive triplex DNA bonds enable parent-daughter templating, while in the second species, triplex binding inhibits the formation of duplex DNA templating. At pH 5.3, the replication rate of species I is ∼1.3-1.4 times faster than that of species II. At pH 7.8, the replication rates are reversed. When mixed together in the same vial, the progeny of species I replicate preferentially at pH 7.8; similarly at pH 5.3, the progeny of species II take over the system. This addressable selectivity should be adaptable to the selection and evolution of multi-component self-replicating materials in the nanoscopic-to-microscopic size range.
- Subjects :
- Nanotechnology
02 engineering and technology
Computational biology
Biology
010402 general chemistry
01 natural sciences
Membrane Microdomains
Exponential growth
DNA origami
General Materials Science
Base sequence
Sensitivity (control systems)
skin and connective tissue diseases
Selection (genetic algorithm)
Base Sequence
Extramural
Mechanical Engineering
DNA
General Chemistry
Replicate
021001 nanoscience & nanotechnology
Condensed Matter Physics
Nanostructures
0104 chemical sciences
Mechanics of Materials
sense organs
0210 nano-technology
Subjects
Details
- ISSN :
- 14764660 and 14761122
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Nature Materials
- Accession number :
- edsair.doi.dedup.....0f864361febc4cf0db48991016d2f0f0