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Myofilaments: Movers and Rulers of the Sarcomere
- Source :
- Comprehensive Physiology
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Striated cardiac and skeletal muscles play very different roles in the body, but they are similar at the molecular level. In particular, contraction, regardless of the type of muscle, is a precise and complex process involving the integral protein myofilaments and their associated regulatory components. The smallest functional unit of muscle contraction is the sarcomere. Within the sarcomere can be found a sophisticated ensemble of proteins associated with the thick filaments (myosin, myosin binding protein-C, titin, and obscurin) and thin myofilaments (actin, troponin, tropomyosin, nebulin, and nebulette). These parallel thick and thin filaments slide across one another, pulling the two ends of the sarcomere together to regulate contraction. More specifically, the regulation of both timing and force of contraction is accomplished through an intricate network of intra- and interfilament interactions belonging to each myofilament. This review introduces the sarcomere proteins involved in striated muscle contraction and places greater emphasis on the more recently identified and less well-characterized myofilaments: cardiac myosin binding protein-C, titin, nebulin, and obscurin. © 2017 American Physiological Society. Compr Physiol 7:675-692, 2017.
- Subjects :
- Sarcomeres
0301 basic medicine
Myofilament
Muscle Proteins
Obscurin
macromolecular substances
Protein Serine-Threonine Kinases
Sarcomere
03 medical and health sciences
Nebulin
Myofibrils
Humans
Connectin
Muscle, Skeletal
biology
Chemistry
Striated muscle contraction
Troponin
030104 developmental biology
Nebulette
Myosin binding
biology.protein
Biophysics
Myofibril
Rho Guanine Nucleotide Exchange Factors
Muscle Contraction
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Comprehensive Physiology
- Accession number :
- edsair.doi.dedup.....0f84a3bf9b4227f691b3a499197499e0