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Accelerated Progression of Hepatocellular Carcinoma during Immunosuppressive Therapy with Abatacept for Rheumatoid Arthritis
- Source :
- Internal Medicine
- Publication Year :
- 2018
- Publisher :
- The Japanese Society of Internal Medicine, 2018.
-
Abstract
- Abatacept, a cytotoxic T lymphocyte antigen-4 immunoglobulin recombinant fusion protein, is an immunosuppressive agent indicated for rheumatoid arthritis. Although no significant increase in malignancy has been reported in abatacept-treated patients, whether or not abatacept accelerates tumor progression in specific cancer types remains unclear. We herein report a 66-year-old woman who showed unusually rapid progression of hepatocellular carcinoma following abatacept therapy for rheumatoid arthritis. Abatacept was speculated to have accelerated her hepatocellular carcinoma progression in the setting of her preexisting risk factors: autoimmune hepatitis and long-term methotrexate use. We propose close tumor surveillance be performed during abatacept therapy, especially for high-risk patients.
- Subjects :
- Oncology
musculoskeletal diseases
medicine.medical_specialty
abatacept
Carcinoma, Hepatocellular
immunosuppressive therapy
Case Report
Autoimmune hepatitis
030204 cardiovascular system & hematology
Malignancy
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
cancer immunity
Internal medicine
Internal Medicine
medicine
Humans
Aged
business.industry
Abatacept
Liver Neoplasms
Cancer
General Medicine
hepatocellular carcinoma
medicine.disease
Methotrexate
Tumor progression
cytotoxic T lymphocyte antigen-4 (CTLA-4)
Hepatocellular carcinoma
Rheumatoid arthritis
Antirheumatic Agents
Disease Progression
030211 gastroenterology & hepatology
Female
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 13497235 and 09182918
- Volume :
- 58
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi.dedup.....0f8357fd65d29453529d8a1abe7cd210