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Onset of symptomatic effect of mometasone furoate nasal spray in the treatment of nasal polyposis
- Source :
- The Journal of allergy and clinical immunology. 121(4)
- Publication Year :
- 2007
-
Abstract
- The efficacy of the intranasal corticosteroid mometasone furoate nasal spray (MFNS) for treatment of nasal polyposis was demonstrated in 2 large clinical trials.To evaluate the onset of MFNS symptomatic effect, data from the 2 trials were pooled and analyzed to determine the first day subjects experienced significant symptom relief.Subjects with nasal polyposis randomized to MFNS 200 microg twice daily or placebo scored symptoms on a 3-point scale (0 = none; 3 = severe) and measured peak nasal inspiratory flow immediately before the morning dose. Onset of symptomatic effect was defined as the first day a statistically significant (P.05) lasting response was observed for MFNS compared with placebo.A total of 447 subjects with bilateral nasal polyps and clinically significant nasal congestion/obstruction were analyzed. Compared with placebo, MFNS 200 microg twice daily demonstrated statistically significant (P.05) relief of anterior rhinorrhea by day 2 (-10.9% vs +5.7%), nasal congestion by day 3 (-15.1% vs -7.6%), postnasal drip by day 5 (+1.1% vs +4.6%), and sense of smell by day 13 (-9.6% vs -5.6%). Significant improvement in peak nasal inspiratory flow was seen by day 2 (increase of 6.22 L/min vs 1.48 L/min for placebo; P = .03).Mometasone furoate nasal spray 200 microg twice daily rapidly improves the symptoms of nasal polyposis, leading to lasting relief of most major symptoms within 2 (24 hours after the first dose) to 5 days of initiating therapy.
- Subjects :
- Adult
Male
Rhinitis, Allergic, Perennial
Adolescent
medicine.medical_treatment
Immunology
Mometasone furoate
Nasal congestion
Placebo
Nasal Polyps
Double-Blind Method
Anti-Allergic Agents
otorhinolaryngologic diseases
Immunology and Allergy
Medicine
Humans
Nasal polyps
Pregnadienediols
Administration, Intranasal
Aged
business.industry
Middle Aged
medicine.disease
Asthma
Nasal decongestant
Smell
Nasal Decongestants
Nasal spray
Anesthesia
Peak Nasal Inspiratory Flow
Nasal administration
Female
medicine.symptom
business
Mometasone Furoate
Inspiratory Capacity
medicine.drug
Subjects
Details
- ISSN :
- 10976825
- Volume :
- 121
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of allergy and clinical immunology
- Accession number :
- edsair.doi.dedup.....0f80b8a7315bef3c19c97ad693714f53