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Carotid atherosclerosis promotes the progression of Alzheimer's disease: A three-year prospective study
- Source :
- Experimental and Therapeutic Medicine
- Publication Year :
- 2017
- Publisher :
- Spandidos Publications, 2017.
-
Abstract
- Although cerebrovascular diseases have been considered as risk factors for cognitive decline and dementia, the associations between atherosclerosis and Alzheimer's disease (AD) have not been fully examined and remain controversial. The aim of this three-year prospective study was to investigate whether arotid artery atherosclerosis accelerates cognitive impairment in AD patients. The association of carotid intimal medial thickness (IMT) with prospective trajectories of cognitive function was assessed among 521 patients with light to moderate AD, and 437 AD patients were followed up annually for 3 years. Participants underwent initial carotid ultrasonography and repeated neuropsychological testing every year. Mixed-effects regression analyses were adjusted to estimate the effect of carotid IMT and other adjusting variables. The results of the present study indicated that carotid IMT was significantly associated with various measures of cognitive function. Furthermore, AD patients with higher carotid IMT values had a faster decline in cognitive scores in a variety of neuropsychological tests, particularly in verbal and non-verbal memory, semantic fluency and executive function. The present prospective study showed that carotid atherosclerosis is a predictive factor regarding the progression of cognitive impairment in AD patients, suggesting that early detection and treatment of vascular risk factors may prevent or at least postpone the evolution of the disease.
- Subjects :
- Cancer Research
medicine.medical_specialty
neuropsychology
Disease
030204 cardiovascular system & hematology
Biology
03 medical and health sciences
0302 clinical medicine
Immunology and Microbiology (miscellaneous)
Internal medicine
carotid intimal medial thickness
medicine
Dementia
cardiovascular diseases
Cognitive decline
Prospective cohort study
cognitive impairment
Carotid ultrasonography
Neuropsychology
Cognition
Articles
General Medicine
Alzheimer's disease
medicine.disease
medicine.anatomical_structure
Immunology
cardiovascular system
Cardiology
progression
atherosclerosis
030217 neurology & neurosurgery
Artery
Subjects
Details
- ISSN :
- 17921015 and 17920981
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....0f6bb81b5e818b973415b687d43ae446