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Cu(I)-Catalyzed Asymmetric α-Allenylation of Activated Ketimines with 3-Butynoates
- Source :
- Organic letters. 22(12)
- Publication Year :
- 2020
-
Abstract
- An asymmetric α-regioselective allenylation reaction of activated ketimines with 3-butynoates is disclosed under Cu(I) catalysis, probably via the generation of nucleophilic γ-allenylcopper species in the presence of diisopropylethylamine. A broad range of imines, derived from diverse ketones such as isatins, pyrazolediones, isoquinoline-1,3,4-triones, and even trifluoromethyl alkynyl ketones, can be utilized, generally affording the corresponding α-allenyl amine derivatives in high yields (≤97%) with excellent enantioselectivities (≤99% ee).
Details
- ISSN :
- 15237052
- Volume :
- 22
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....0f686fdd0878e37a0ba81145d7f2cf09